The Effect of Dandang Gendis Extract (Clinacanthus nutans) on Kidney Histopathological Features of Diabetic Rats Model

Changes in kidney homeostasis due to diabetes can cause oxidative stress which then caused tissue damage that leads diabetic nephropathy. Clinacanthus nutans extract is known contain antioxidants are reported play an important role the body’s defense system against minimize damage. This study aims know effect of leaf administration on histopathological features rats model. A total 35 were induced by streptozotocin divided into 5 groups and given with a dose 75 mg/kgBW, 150 mg/kgBW 300 compare CMC-Na as control metformin standard drug for 14 days. The histopathology was evaluated under light microscope criteria occurred proximal tubules kidney. As result least amout treatment group at followed metformin. In conclusion improve feature model.
 
 Keywords: mellitus; histopathology; nephropathy;